Lee JY, et al. - Using a screening colonoscopy database of 13,618 asymptomatic subjects (30–49 years old) and 17,999 subjects (50–75 years old), a cross-sectional study was performed to examine the prevalence of sessile serrated polyps (SSPs) and the relationship between SSP risk and modifiable lifestyle factors in asymptomatic young adults. The prevalence of SSP was 2.0% in subjects 30–49 years old. It was noted that the relationship between anatomic location and ≥ 20 pack-years of smoking was stronger for distal SSPs than for proximal SSPs. In an analysis of a colonoscopy screening database, they found that smoking and alcohol consumption were related to any SSPs and large SSPs in asymptomatic young adults. Five years of cessation of smoking decreased the risk of SSPs and large SSPs. For the primary prevention of SSPs in young adults, early lifestyle changes might, therefore, be recommended.