Pornpattananangkul N, et al. - Through a large-scale cross-sectional functional magnetic resonance imaging study on 2,878 anhedonia children, the researchers intended to investigate the specificity of the changes in anhedonia against other clinical phenotypes (low mood, anxiety, and attention-deficit/hyperactivity disorder) and to map the changes in intrinsic large-scale connectivity and task-evoked activation. Altered activation during working memory and intrinsic large-scale connectivity and task-evoked activation during reward anticipation were shown by those with ADHD and anhedonia respectively. Lack of intrinsic reward-arousal integration during rest and decreased extrinsic reward-arousal activity during reward anticipation complementarily mapped anhedonia onto aberrations in neural-cognitive processes when hypoconnectivity at rest and hypoactivation during reward anticipation was noted. The pathophysiological underpinnings of anhedonia in children via findings were delineated.