Katsimpris A, Jürgens C, Lüdtke L, et al. - Via analyzing cross-sectional data from the population-based Study of Health in Pomerania (2008–2012), researchers ascertained if cardiorespiratory fitness (CRF) and handgrip strength, two objective markers of physical fitness, are correlated with age-related macular degeneration (AMD). The sample consisted of 1,173 adult men and women aged 20 to 79 years. Fundus photography of the central retina was captured with a non-mydriatic camera, and images were graded by an experienced reader according to an established clinical AMD classification scale. According to a modified Jones protocol, CRF was measured using peak oxygen uptake (peakVO₂), oxygen uptake at the anaerobic threshold (VO₂@AT), and maximum power output (W_max) from standardised cardiopulmonary exercise testing on a bicycle ergometer. AMD was not associated with peakVO₂, VO₂@AT, W_max and handgrip strength. Findings suggested no association of CRF and handgrip strength with AMD. However, longitudinal studies with larger sample sizes are needed to further examine these associations.