Rossello X, Fuster V, Oliva B, et al. - In this cross-sectional study involving 3,909 middle-aged asymptomatic people, researchers sought to explore the connection between body size phenotypes and subclinical atherosclerosis. In total, 6 cardiometabolic body size phenotypes have been defined based on the presence of at least 1 cardiometabolic abnormality (BP, fasting blood glucose, triglycerides, low high-density lipoprotein cholesterol, homeostasis model assessment-insulin resistance index, high-sensitivity C-reactive protein) and based on BMI: normal-weight (NW; BMI < 25), overweight (OW; BMI = 25.0-29.9) or obese (OB; BMI > 30.0). Subclinical atherosclerosis was assessed by 2D vascular ultrasonography and noncontrast cardiac computed tomography. For metabolically healthy individuals, the presence of subclinical atherosclerosis increased across BMI categories, while fewer variations were noted for metabolically unhealthy people. Subclinical atherosclerosis prevalence differs across body size phenotypes. By facilitating the transition from one phenotype to another, pharmacologic and lifestyle interventions may alter their cardiovascular risk.