Association between body mass index and surgical menopausal symptoms in patients with early stage endometrial cancer
Gynecologic Oncology Jan 18, 2019
Cripe JC, et al. -In this retrospective review, researchers investigated the link between body mass index (BMI) and surgical menopausal symptoms in endometrial cancer patients who had menopause secondary to surgical staging procedure. They performed a univariate analysis and used Poisson regression models to generate relative risks. Severe symptoms were defined as those which required a prescription for treatment; those for which treatment was offered, but declined, were classified as mild symptoms. Surgical menopause symptoms were reported by 65 (39.2%) women, including 19 (11.4%) mild and 46 (27.7%) severe. Symptom type did not differ by BMI, however, with increasing BMI, decrease in the prevalence of severe menopausal symptoms was observed: BMI<30 (45.5%), BMI 30–39.9 (30.6%), BMI 40–49.9 (22%), and BMI ≥ 50 (14.7%); this was found to be true when tested in multivariate analysis. Menopausal symptoms after oophorectomy were significantly less likely to be seen in women younger than 50 with BMI >40 and stage I endometrial cancer vs women with BMI <30. This information may assist in peri-operative counseling.
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