Monti S, Craven A, Klersy C, et al. - This study was sought to exhibit that changes in disease presentation and 6 month outcome between younger- and older-onset patients are still incompletely understood. Between October 2010 and January 2017, researchers recruited patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis study with a diagnosis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). They classified the population according to age at diagnosis: < 65 years or ≥ 65 years. Correlations were adjusted for the type of AAV and the type of ANCA (anti-MPO, anti-PR3 or negative). This study included a sum of 1,338 patients with AAV: 66% had disease onset at < 65 years of age [female 50%; mean age 48.4 years (S.D. 12.6)] and 34% had disease onset at ≥ 65 years [female 54%; mean age 73.6 years (S.D. 6)]. Compared with younger patients, individuals > 65 years of age show a different pattern of organ involvement and an elevated risk of significant damage and mortality within 6 months of diagnosis of AAV.