Chung GE, et al. - Researchers conducted a prospective cohort study to assess the effect of fatty liver (diagnosed by ultrasonography) disease and advanced fibrosis (defined as high probability of advanced fibrosis based on 3 noninvasive methods, aspartate aminotransferase-to-platelet ratio index, nonalcoholic fatty liver disease fibrosis score, and FiB-4 score) on overall morality with a focus on body size and abdominal fat distribution measured by computed tomography (CT). Participants in the study were 34,080 subjects (mean age, 51.4 years; 58.6% men) who had abdominal ultrasonography and fat CT, from 2007 to 2015. Data reported that the prevalence of fatty liver disease was 37.5%, on the other hand, the prevalence of advanced fibrosis in the fatty liver disease was 1.8%. Two hundred ninety-six deaths occurred during a median follow-up of 87 months. Although fatty liver disease did not affect mortality overall, subcutaneous adiposity was linked to decreased overall mortality. Advanced fibrosis has been an independent predictor of an increase in overall mortality.