Liang D, et al. - In this retrospective observational study including 1,865 consecutive patients with acute coronary syndrome (ACS), researchers evaluated the prognostic impact of admission lactate level on survival using Cox proportional hazards models. They categorized participants into tertiles of lactate level (T1: < 1.8; T2: 1.8–2.6; T3: ≥ 2.7 mmol/l). They assessed 30- and 180-day mortality from hospital admission. According to findings, elevated admission lactate level independently predicted 30- and 180-day all-cause mortality in patients with ACS. Admission lactate level was found to be significantly positively associated with both 180- and 30-day mortality, with the highest risk for lactate ≥ 2.7 mmol/l. For 180-day mortality, the estimated adjusted hazard ratio was 2.09 for T3 and 1.53 for T2 vs T1, and 1.10 for each unit increase in lactate level. For 30-day mortality, similar trends were reported. Across all subgroups studied, the association was found to be highly consistent.