Núñez-Torres R, Martín M, García-Sáenz JA, et al. - Researchers, for the first time, sought to explore the connection between a regulatory variant in the ABCB1 gene and the occurrence of persistent chemotherapy-induced alopecia (pCIA) in patients with breast cancer who were treated with docetaxel-based therapies. For this genetic association study, 215 women with breast cancer (median age, 51.6 years; interquartile range, 44-60 years) treated with docetaxel-based chemotherapy with a follow-up of 1.5 to 10 years after the end of the treatment were enrolled retrospectively by 3 hospital oncology units across Spain between 2005 and 2018. The authors found genetic variants in the ABCB1 gene that were significantly related to the risk to develop persistent chemotherapy-induced alopecia. This finding suggests a significant insight into the biological mechanisms underlying pCIA and opens the possibility to explore these patients' personalized treatment.