Garvey SL, Khansari MM, Jiang X, et al. - In this nested case-control study, researchers sought to examine alterations in retinal vascular oxygen saturation (SO₂), vessel diameter (D) and tortuosity at severity stages of diabetic retinopathy (DR) in African-American (AA) individuals (n = 56). The right eyes were classified as non-diabetic (ND) (N = 26), no clinical DR (NDR) (N = 19), or moderate/severe non-proliferative DR (NPDR) (N = 11). Using a commercially available scanning laser ophthalmoscope, imaging was performed. Compared with ND and NDR groups, SO_2V and DV were higher in NPDR. The findings advance understanding of DR pathophysiology in the AA population and may contribute to race-specific retinal vascular biomarkers being identified for improved diagnosis and monitoring of DR.