Munblit D, et al. - This study was undertaken to determine if cow’s milk allergy (CMA) guideline recommendations could promote CMA overdiagnosis or undermine breastfeeding. Nine CMA guidelines published from 2012 to 2019 were reviewed. Seven suggest that CMA is a cause of common infant symptoms. Seven recommended strict maternal cow milk exclusion for the management of common symptoms in breastfed infants. Approximately 1% of infants have been found to be affected by CMA proven to be a food challenge, while 15% to 20% of infants have reported distressing crying, vomiting, or rashes. Recommendations for the management of common infant symptoms such as CMA are not evidence-based, particularly in breastfed infants who do not consume cow's milk directly. Such guidelines can cause harm by undermining confidence in breastfeeding.