Phillips GS, Freret ME, Friedman DN, et al. - Researchers sought to report on the clinical features, associated factors, and treatment response of Persistent radiation-induced alopecia (pRIA) in patients with primary central nervous system (CNS) tumors or head and neck sarcoma. At 2 large tertiary care hospitals and comprehensive cancer centers, they conducted a retrospective cohort study of 71 children and adults diagnosed with primary CNS tumors or head and neck sarcomas evaluating pRIA. The patients showed localized, diffuse, or mixed patterns of alopecia with frequent white patches on trichoscopy. They observed severe alopecia in association with greater scalp radiation dose and proton irradiation. Improvement in alopecia was noted in 82% of patients treated with topical minoxidil, 5%, solution and 100% of patients managed surgically. This suggests topical minoxidil as effective in improving alopecia observed in most cases with persistent radiation-induced alopecia, and surgical procedures as possibly effective in nonresponders.