Phillips GS, Freret ME, Friedman DN, et al. - In this retrospective cohort study involving 71 patients (median [range] age, 27 [4-75] years; 51 female [72%]), researchers sought to describe persistent radiation-induced alopecia (pRIA) in patients with primary central nervous system (CNS) tumors or head and neck sarcoma. According to results, alopecia had localized, diffuse, or mixed localized plus diffuse patterns with frequent white patches on trichoscopy. Findings suggested an association of severe alopecia with greater scalp radiation dose and proton irradiation. Improvement in alopecia has been noted in 82% of patients treated with topical minoxidil, 5%, solution, and 100% surgically treated patients. There was no statistically important relation between hair density and scalp radiation dose. Persistent radiation-induced alopecia in patients with primary CNS tumors or head and neck sarcomas is a dose-dependent phenomenon with distinctive clinical and trichoscopic characteristics. The findings of this study indicate that the treatment of pRIA may benefit from topical minoxidil and procedural interventions.