Thomas C, et al. - The potential return on investment of the National Health Service Diabetes Prevention Programme (NHS DPP) was investigated in England. This trial also aimed at determining which population subgroups exhibited greater tendency to benefit most in terms of cost-effectiveness, cost-savings and health benefits. This program appeared to be cost-effective and cost-saving under current assumptions. Prioritising obese individuals could create the most value for money and obtain the greatest health benefits per individual targeted. Low socioeconomic status or ethnic minority groups possibly attained fewer quality-adjusted life-years (QALYs) per intervention. Hence, these strategies ought to be targeted to ensure that the DPP did not contribute to widening health inequalities. The differential responsiveness of population subgroups to the DPP warranted additional analyses.