Guo CG, Ma W, Drew DA, et al. - In this pooled analysis of two cohort studies that included 94,540 participants (mean [SD] age, 76.4 [4.9] years for women, 77.7 [5.6] years for men; 67,223 women [71.1%]; 65 259 White women [97.1%], 24,915 White men [96.0%]) aged 70 years or older, researchers sought to explore the connection between aspirin use and the risk of incident colorectal cancer (CRC) among older adults. Compared with nonregular use, regular use of aspirin at or after age 70 years has been correlated with a lower risk of CRC. This risk reduction, however, was only apparent in individuals who initiated use at a younger age. Such results indicate that initiation of aspirin use at an older age for the purpose of primary prevention of CRC should be discouraged, but the findings support guidelines for continuation of aspirin use if initiated at a younger age.