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Aspirin as an antifungal-lock agent in inhibition of candidal biofilm formation in surgical catheters

Infection and Drug Resistance Apr 17, 2021

Chan AKY, Tsang YC, Chu CH, et al. - Researchers aimed at examining the anti-biofilm effect of aspirin on Candida biofilms including C. albicans, C. glabrata, C. krusei and C. tropicalis formed on surgical catheters. Further, they determined the concentration and time required to eradicate the biofilms. They grew biofilms of Candida species on silicone catheters and incubated them in aspirin at different concentrations for 2, 4 and 24 hours. Per outcomes, C. albicans was the most sensitive species towards aspirin among the tested Candida species. Aspirin at a concentration of 40 mg/mL in 4 hours was effective in eradicating the biofilm. Aspirin led to eradication of all the other tested species at a concentration of 40 mg/mL in 24 hours. Aspirin is thus suggested to have utility as an anti-fungal agent in lock therapy in the treatment of catheter-related candidemia.

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