Thomas KR, et al. - Researchers investigated reasons low mild cognitive impairment (MCI)-to-cognitively normal (CN) reversion rates were seen in the Alzheimer's Disease Neuroimaging Initiative (ADNI), as ADNI has a very low 1-year mild cognitive impairment (MCI)-to-normal reversion rate of 3%. They identified CN and MCI participants as staying stable, progressing, or reverting at 1-year of follow-up (Year 1). Impaired memory was not seen in 22.5% of subjects classified as stable MCI at Year 1. Further, these subjects had biomarkers more comparable to those of cognitively normal subjects. The Clinical Dementia Rating seemed to influence the year 1 MCI diagnosis more than memory performance. Results thus demonstrate that ADNI-diagnosed participants display an artificially low 1-year MCI-to-CN reversion rate. The reversion rate would be 21.8% on consistently applying the memory cutoffs.