Tani C, Zucchi D, Haase I, et al. - Researchers examined 347 pregnancies observed in 281 SLE patients, which were prospectively monitored by pregnancy clinics at four rheumatology centres, with the aim to determine if disease remission or low disease activity state at the beginning of pregnancy in SLE patients is linked with better pregnancy outcome. After exclusion of early pregnancy losses, they identified occurrence of 212 pregnancies (69.7%) in patients who were in remission at baseline, 33 (10.9%) in patients in Lupus Low Disease Activity State (LLDAS), and the remainder in active patients. Multivariate analysis revealed less likelihood to have disease flare among patients in disease remission or taking hydroxychloroquine, while increased risk was observed in correlation with a history of lupus nephritis. Patients with shorter disease duration were noted to be at increased risk of APOs, while being on hydroxychloroquine was noted to be a protective variable. Complete remission and a decreased risk of APOs were almost significantly associated. Based on these findings, they suggest prenatal planning with a firm treat-to-target goal of disease remission as a relevant strategy to lower the risk of disease flares and severe obstetrical complications in SLE pregnancies.