Hernandez NM, Cunningham DJ, Hinton ZW, et al. - This study was intended to evaluate whether individuals taking pre-operative benzodiazepines would have elevated complications following total knee arthroplasty (TKA). Researches assessed patients undergoing primary TKA who either did or did not have a pre-operative record of benzodiazepine prescription applying a nationwide database between 2010 and 2019. They conducted a multivariable logistic regression analysis, adjusting for multiple variables (age, gender, obesity, and Charlson comorbidity index), to ascertain the relationship of pre-operative benzodiazepine use and adverse events in a matched cohort. They assessed 90-day and 2-year rates of revision, resection, femur fracture fixation, manipulation under anesthesia (MUA), and delirium. The findings revealed that benzodiazepine use was correlated with elevated rates of revision, resection, femur fracture fixation, and delirium after controlling for multiple variables. The outcomes indicated that benzodiazepine use was also correlated with a decreased rate of MUA. The outcomes suggested that orthopedic professionals can counsel patients taking this group of medications about the correlated adverse events. Future trials should evaluate the use of other muscle relaxants in the prevention of knee stiffness and MUA.