Krebs J, Pannek J, Rademacher F, et al. - A rretrospective cohort study was conducted to evaluate the impacts of 200-unit onabotulinumtoxin A detrusor injections on neurogenic detrusor overactivity (NDO) in patients who have previously been treated with 300-unit injections. Researchers screened the patient database for patients with NDO as a result of chronic (≥ 12 months) spinal cord injury (SCI), who had been treated with 300- followed by 200-unit onabotulinumtoxin A detrusor injections. They obtained patient characteristics, bladder management data and concurrent bladder medication as well as urodynamic data. This study estimated the percent variations in the urodynamic parameters from the 300- to the 200-unit treatment phase to test for non-inferiority of the 200-unit treatment. Researchers examined the data of 61 individuals with a mean age of 44 ± 15 years (range 18–73 years) and a mean 13.2 ± 9.5 years (range 2–43 years) since SC. The data showed that in patients with chronic SCI, the treatment of NDO with 200 units of onabotulinumtoxin A was not inferior to a 300-unit treatment regarding urodynamic parameters.