Oh ES, Needham DM, Nikooie R, et al. - Via performing a systematic review of 14 randomized, controlled trials, researchers determined the benefits and harms of antipsychotics for the prevention of delirium in adults. They found that the use of haloperidol vs placebo for delirium prevention resulted in no differences in delirium incidence or duration, hospital length of stay (high strength of evidence), and mortality. Gained evidence thus does not support the routine use of haloperidol or second-generation antipsychotics for prevention of delirium. Evidence was limited regarding the lowering effect of second-generation antipsychotics on the incidence of delirium in postoperative patients. Overall, short-term use of antipsychotics may lead to neurologic harms. Some of the trials indicated the more frequent occurrence of potentially harmful cardiac effects with antipsychotic use.