de la Sierra A, et al. - Researchers investigated the possible associations of antihypertensive drug classes, specific agents inside each class, and types of combinations, with the presence of non-treatment-resistant hypertension (TRH) vs TRH, and with controlled vs uncontrolled TRH. Patients treated with three drugs and at least four drugs were assessed separately, and associations were adjusted for age, sex, and previous cardiovascular event. In both groups of patients (those treated with three or four or more drugs), the use of aldosterone antagonists was found to be related to blood pressure control. They observed similar results with specific agents, such as ramipril, olmesartan, and amlodipine. The burden of TRH might probably be attenuated with an increased use of these drugs.