Andrade C, et al. - Researcher sought to ascertain if depression alone or its treatment with antidepressant drugs as well is related to the increased fracture risk in the elderly, in persons with depression, and in those who receive antidepressant drugs. In a recent observational study, investigation regarding the risk of fracture was done not only in the year after antidepressant initiation but also in the year before antidepressant initiation. In all of 10 time-windows during the 2 years, a significantly increased risk of fracture was observed; in fact, the highest risks was observed in the weeks to months before antidepressant initiation. The analysis suggests a significantly increased risk of hip fracture in correlation with untreated depression. The patients were noted to be at elevated risk during the year after antidepressant initiation; it may be due to the persistence of depression-related mechanisms and by incompletely remitted depression. However, a contribution from ongoing antidepressant exposure cannot be ruled out.