Stolz L, et al. – Whether or not long–term anticoagulation with warfarin or rivaroxaban had beneficial effects on the course of autoimmune experimental encephalomyelitis (EAE), was examined in this study. Long–term anticoagulation models were developed. These models permitted exploring the course of EAE under warfarin and rivaroxaban treatment. A mild preventive effect of both warfarin and rivaroxaban reveled on neurological deficits and local inflammation. It demonstrated a modulation of the disease induction by anticoagulation.