Antibody concentrations decrease 14-fold in children with celiac disease on a gluten-free diet but remain high at 3 months
Clinical Gastroenterology and Hepatology Apr 30, 2018
Petroff D, et al. - The target of the researchers was to gauge the concentrations of immunoglobulin A (IgA) against tissue transglutaminase (IgA-TTG) in children with celiac disease, placed on a gluten-free diet (GFD). Eligible candidates included pediatric patients (mean age, 8.4 years) who underwent duodenal biopsy to confirm or refute celiac disease from October 2012 through December 2015. A notable decrease was found in the serum concentration of IgA-TTG in most children with celiac disease within 3 months after they were placed on a GFD. Nonetheless, it did not normalize in most. Yielded data could aid in analyzing the patient response to the diet at short-term follow-up evaluations. It was deduced that subjects with a significant response to a GFD displayed persistently high antibody levels after 3 months.
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