Andrikopoulou M, et al. - Researchers analyzed antibiotic use during delivery hospitalizations in the United States via analyzing an administrative inpatient database that includes medications in women delivering, from January 2006 to March 2015. They included 5,657,523 women admitted for delivery hospitalization [1,899,374 (33.5%) delivered via cesarean and 3,758,149 (66.4%) via vaginal delivery]. Antibiotics were administered to 3,235,106 (57.2%) of women including 1,547,060 during vaginal (41.1%) and 1,688,046 (88.9%) during cesarean hospital. During cesarean, they noted an increase in the antibiotics use from 87.3% in 2006 to 89.5% in 2015 while the use of antibiotics decreased for vaginal deliveries from 47.7% to 34.0%. Cephalosporins were the most common antibiotic administered (50.1% of all hospitalizations) followed by penicillins (36.2%) and macrolides (36.2%). In the setting of specific indications, the proportion of women undergoing vaginal delivery receiving antibiotics increased with GBS positive women accounted for 43.0% of women in 2015 vs 30.8% in 2006. Similarly, they noted a significant increase in the proportion of women undergoing vaginal delivery receiving antibiotics for PPROM (4.9% to 7.9%), chorioamnionitis (2.0% to 4.5%), and endometritis (0.2% to 0.4%) from 2006 to 2015.