Longo UG, Candela V, Facchinetti G, et al. - A systematic review was conducted to assess the efficacy of antimicrobial prophylaxis in periprosthetic joint infection (PJI) in shoulder replacement and to provide health workers with the best approach to the use of antimicrobial agents based on currently available clinical evidence. This study was carried out in accordance with the preferred reported Items of systematic review and meta-analysis statement. Researchers enrolled studies concerning the effectiveness of antimicrobial prophylaxis in the prevention of PJI in patients undergoing shoulder replacement. This study population consisted of 3,272 patients who had undergone a surgical procedure, most of which were males. The data demonstrate that the optimal perioperative antimicrobial regimen is controversial. The findings reveal that clinical guidelines recommend the usage of only one antibiotic as prophylaxis but considering the increase in the rates of antibiotic-resistant infections, the question arises if antibiotic prophylaxis should be extended for adequate coverage. After surgery, shoulder arthroplasty conducted on the male population must be carefully checked for the possible presence of P. Acnes.