Shein SL, et al. - Researchers performed a retrospective cohort study at 46 children’s hospitals in the United States, to delineate antibiotic prescribing practices during the first 2 days of mechanical ventilation among previously healthy young children with respiratory syncytial virus–associated lower respiratory tract infection and to examine associations between the prescription of antibiotics at onset of mechanical ventilation with clinical outcomes. Observations revealed high variability and a reduction over time in the practice of instituting antibiotics after intubation in young children with respiratory syncytial virus–associated lower respiratory tract infection across centers. However, these practices were noted to be associated with a shortened clinical course after adjustment for the limited available covariates. This study suggests the necessity for a prudent approach to identify and optimally treat bacterial coinfection.