Yoon BH, et al. - Researchers examined whether intra-amniotic infection or intra-amniotic inflammation in patients with preterm labor and intact membranes could be eradicated using antibiotics. Women who met the following criteria were included in this study: 1) singleton gestation between 20-34 weeks; 2) preterm labor and intact membranes; 3) transabdominal amniocentesis performed for the evaluation of the microbiologic/inflammatory status of the amniotic cavity; 4) intra-amniotic infection and/or inflammation; and 5) received antibiotic treatment which consisted of ceftriaxone, clarithromycin, and metronidazole. Antibiotics were given to 50 of 62 patients with intra-amniotic infection and/or inflammation. In 79% of patients with preterm labor, intact membranes, and intra-amniotic infection/inflammation, they noted eradication of intra-amniotic infection/inflammation. In 84% of patients who underwent follow-up amniocentesis and in 32% of women who received the antibiotic regimen, treatment was successful.