Osaka R, et al. - This paper undertook a comparative analysis of the 12-month efficacy of 1 initial intravitreal injection of an anti-vascular endothelial growth factor (VEGF) agent followed by pro re nata (PRN) dosing with that of 3 initial monthly injections followed by PRN dosing, in patients with macular edema (ME) after central retinal vein occlusion (CRVO). Similar 12-month outcomes were yielded with a 1+PRN regimen than those of a 3+PRN regimen with fewer injections when used for ME after CRVO.