Magalhães A, Carvalho LP, Costa R, et al. - The accuracy of anti-Leishmania IgG and IgG subclasses in differentiating clinical forms of American tegumentary leishmaniasis (ATL) was determined, and the relationship between antibodies levels with cytokine production and severity of ATL was examined. Researchers examined IgG and subclasses of IgG to soluble Leishmania antigen, as well cytokine levels in supernatants of mononuclear cells by ELISA among 40 cutaneous leishmaniasis (CL), 20 mucosal leishmaniasis (ML), 20 disseminated leishmaniasis (DL) patients and 20 individuals with subclinical L. braziliensis infection (SC). Overall 95%, 95% and 100% of CL, ML and DL patients, respectively, had detection of IgG. As per findings, high Anti-Leishmania IgG and IgG2 levels characterize DL, and while there was correlation of IgG with pro-inflammatory cytokines and direct correlation of IgG2 with number of lesions.