Kim JE, et al. - Researchers clarified whether or not the anti-inflammatory function of phelligridin D affects periodontal regeneration for supporting the human periodontal ligament cells (HPDLCs) of teeth. As per data, teeth were supported by phelligridin D on the alveolar bone against outside stress and for the prevention of periodontitis or periodontal regenerative related disease this may be used as an anti-inflammatory compound. Moreover, antioxidant properties were demonstrated by phelligridin D by reducing reactive oxygen species activity. Finally, the periodontal differentiation of HPDLCs was promoted by the anti-inflammatory and antioxidant function of phelligridin D.