Sadek SH, Ahmed MN, Kamal MA, et al. - In this prospective randomized interventional study, researchers sought to compare the outcome of a conservative treatment to surgical intervention for the treatment of large anterior chamber (AC) granulomas presenting with moderate-severe anterior uveitis. The sample consisted of 39 patients (41 eyes) with active AC granuloma ≥ 3 mm (flare & cells ≥ +2). Study participants were randomly assigned to either conservative treatment in the form of topical prednisolone and cycloplegic drops with orbital floor (transseptal) injection of Triamcinolone acetonide (20 eyes) or surgery in the form of granuloma excision and AC wash (21 eyes). Surgical treatment of large granulomas results in a more complete and rapid resolution of inflammation.