Kong X, Xu F, Wang Z, et al. - Researchers conducted this retrospective multicenter study to assess the impacts of antenatal corticosteroids (ACS) administration on mortality and major neonatal complications in the early life of preterm twins. From January 2013 to December 2014, 1,662 twins delivered at 25∼34 ⁺6gestational weeks were retrospectively registered in China. According to weather their mothers received ACS or not, they were divided into ACS group and no-ACS group. They were also subgrouped as 25∼27 ⁺6 and 28∼34 ⁺gestational week groups. In total, 910 neonates (54.8%) received one or more doses of ACS, and 752 neonates (45.2%) did not receive any ACS. Between the ACS and no-ACS groups, no significant difference was found in infant mortality. No significant differences were found in the incidence of bronchopulmonary dysplasia, intraventricular hemorrhage, necrotizing enterocolitis, retinopathy of prematurity, patent ductus arteriosus, sepsis, and severe respiratory distress syndrome (RDS) between the two groups. Multivariable logistic regression analysis showed a reducing risk of RDS after adjusting the gestational week, birth weight, small for gestational age, delivery mode, 5 min Apgar score, and maternal perinatal complications. ACS administration is related to a decreased risk of RDS in twin preterm infants. The data show, however, that it might have a little beneficial impact on mortality and other short-term morbidities.