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Antenatal corticosteriods decrease forced vital capacity in infants born fullterm

Pediatric Pulmonology Jul 14, 2020

Bandyopadhyay A, Slaven JE, Evrard C, et al. - Given that antenatal corticosteroids (ACS) administration to pregnant women for threatened preterm labor is standard obstetric care to lessen neonatal respiratory distress syndrome and the associated respiratory morbidity, researchers tested the assumption that ACS impairs lung growth and performed infant pulmonary function testing, which included spirometry, alveolar volume (VA) and lung diffusion (DL). Thirty-six full‐term infants (17 infants had ACS exposure and 19 infants had no ACS exposure) between 4 to 12 months of age were evaluated. Compared with non‐ACS exposed infants, infants exposed to ACS had a significantly lower forced vital capacity. For the ACS exposed group, FEV0.5 tended to be lower. There was no difference between VA and DL between the two groups. Such findings indicate that ACS can impair subsequent growth of the lung parenchyma.

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