Eckstrand KL, et al. - To evaluate neural reward-processing factors linked with improved psychiatric symptoms and psychosocial function, authors conducted a longitudinal cohort follow-up study from March 1, 2014 to June 5, 2018 with 52 psychologically distressed individuals with age ranging from 18 to 25 years after baseline functional magnetic resonance imaging. A decline in anhedonia symptoms was linked with a higher reward prediction error (RPE) activation in the left ventral striatum. Outcomes were not related to psychotropic medication use. An increase in left ventral striatum responsiveness to RPE may be a biomarker or potential target for the treatment of severe anhedonia, psychosocial function, and mental health.