Al-Bayyari N, Al-Domi H, Zayed F, et al. - Researchers performed this prospective, randomized, double-blind, placebo-controlled clinical study to examine the impact of vitamin D treatment on androgen levels and hirsutism scores in overweight women with polycystic ovary syndrome (PCOS). This investigation was carried out at King Abdullah University Hospital in Irbid, Jordan. Two groups were allocated to overweight Jordanian women aged 18-49 years with vitamin D deficiency and PCOS (n = 60): the treatment group ( n = 30) who received 50,000 IU per week of vitamin D ₃ and the control group ( n = 30) who received a placebo. Total testosterone, parathyroid hormone, free androgen index, and hirsutism score levels were significantly decreased after 12 consecutive weeks of treatment, and levels of 25-hydroxyvitamin D (25(OH)D), sex hormone binding globulin, and phosphorus were significantly increased. In addition, significant changes in ovarian volume and follicle numbers and size ultrasonography, and in the regularity of the menstrual cycle were observed. Overall, the authors concluded that vitamin D ₃ improved 25(OH)D levels and decreased the hirsutism scores and androgen levels of overweight women with PCOS at a treatment dose of 50,000 IU per week. Such findings may indicate increased fertility and enhanced reproductive health for overweight women with PCOS; more consideration should be given to the use of vitamin D ₃ as a treatment for these patients.