Johnson KE, Popratiloff A, Fan Y, et al. - This study was intended to assess the size and shape of talc particles in talcum powder and compare this data to the size and shape of talc particles found in surgically resected tissues from patients with ovarian carcinoma. Researchers conducted this study to evaluate the size and shape of talc particles in samples of talc-containing baby powder (TCBP) and surgically resected pelvic tissues (hysterectomies) from talc-exposed patients with ovarian carcinoma applying polarized light microscopy and scanning electron microscopy. The data, combined with previous epidemiological literature and tissue-based analytical studies, serve further data that the small, isodiametric particles that dominate TCBP can migrate from the perineum and become lodged in distal structures in the female reproductive tract, where they may lead to an elevated risk of developing ovarian carcinoma.