Ma Y, Jun GR, Zhang X, et al. - Via a case-control, whole-exome sequencing study of 10,441 people, researchers recognized APOE genotype-dependent associations with infrequent and rare variants using whole-exome sequencing. Novel genome-wide notable associations were received in the discovery sample with rs536940594 in AC099552 and rs138412600 in GPAA1. GPAA1 was also related to expression in the brain of GPAA1 and its repressive transcription factor, FOXG1, and global cognition function. Notable gene-wide associations were seen for OR8G5, IGHV3-7, and SLC24A3 in 2,377 patients with Alzheimer disease (AD) and 706 controls with ε4. Thus, the study recognized multiple possible novel correlations for AD with individual and aggregated rare variants in groups of individuals with and without APOE ε4 alleles that reinforce known and imply additional pathways resulting in AD.