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Analysis of the association between kidney injury biomarkers concentration and nephritis in immunoglobulin a vasculitis: a pediatric cohort study

International Journal of Rheumatic Diseases Jul 19, 2020

Dyga K, Machura E, Swietochowska E, et al. - The present study was performed to assess the clinical course, selected biochemical parameters and concentrations of renal injury biomarkers such as neutrophil gelatinase‐associated lipocalin (NGAL), kidney injury molecule‐1 (KIM‐1) and liver‐fatty acid binding protein (L‐FABP) in patients with immunoglobulin A vasculitis (IgAV) to distinguish the markers correlated with nephritis in the course of the disease. Researchers included a total of 29 children with IgAV and 34 healthy controls. No evident correlation was found between the concentrations of NGAL, KIM‐1 and L‐FABP and nephritis in the course of IgAV in children. Additionally, a significant male predominance was confirmed in patients with nephritis.

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