Purger DA, Pendharkar AV, Ho AL, et al. - A total of 1,789 index artificial disk replacement (ADR) procedures were recognized in the inpatient database (State Inpatient Databases) in comparison with 370 procedures in the ambulatory cohort (State Ambulatory Surgery and Services Databases) in order to contrast clinical outcomes and cost related between inpatient and ambulatory setting ADR. For individuals who underwent elective ADR in California, Florida, and New York from 2009 to 2011 in State Inpatient and Ambulatory Databases, outcomes and cost were retrospectively assessed. No ambulatory individuals with ADR had to undergo a reoperation within 30 days. Six unique individuals of the inpatient ADR group had undergone reoperation within 30 days. No important variation in emergency department visit rate, inpatient readmission rate, or reoperation rates within 30 days of the index procedure between outpatient or inpatient ADR was noted. In all clinical outcomes, outpatient ADR is noninferior to inpatient ADR. In the outpatient ADR group, Tthe direct cost was markedly lower. In the outpatient ADR group, the 90-day cumulative charges were considerably lower. Hence, ADR could be done in an ambulatory setting with similar morbidity, readmission rates, and lower costs, to inpatient ADR.