Jukic AMZ, et al. - Researchers examined how fecundability is influenced by analgesic use in three different menstrual cycle windows – pre-ovulation, peri-ovulation, and implantation – as well as across the entire menstrual cycle. In this cohort study of women (aged 30 to 44 years) who were trying to conceive naturally from 2008–2015, they classified medication usage as acetaminophen, aspirin, or non-aspirin nonsteroidal anti-inflammatory drug (NSAID) during four time periods of interest using daily diaries. Analyzing 858 women and 2,366 cycles, they identified infrequent medication use. No correlation of using non-aspirin NSAIDs or acetaminophen with fecundability was observed in any of the time windows of interest. Although the sample size was small, increased fecundability was observed in correlation to aspirin use during the implantation window. These results support previous literature reporting that 1) implantation may be a significant target for the effects of aspirin on conception and 2) aspirin may be useful regardless of pregnancy loss history.