Hartley C, et al. - In this single-centre masked trial, the researchers sought to establish whether oral morphine could provide effective and safe analgesia for acute procedural pain in unventilated premature infants. For this investigation, 31 infants were randomly allocated at the John Radcliffe Hospital, Oxford, UK, using a web-based facility with a minimisation algorithm to either 100 μg/kg oral morphine sulphate or placebo 1 h before a clinically required heel lance and retinopathy of prematurity screening examination, on the same occasion. Oral morphine (100 μg/kg) administration to non-ventilated premature infants has the potential for harm without analgesic efficacy. Oral morphine for retinopathy of prematurity screening was not recommended and strongly advise caution when considering its use for other acute painful procedures in non-ventilated premature infants.