Panday RSN, et al. - In this sub-analysis of a randomized controlled trial (PHANTASi- Prehospital Antibiotics Against Sepsis trial) that report the impact of prehospital antibiotics in sepsis patients, researchers assessed how patient outcomes were affected clinically by the presence of a positive culture vs a negative culture. They also examined how culture outcomes were influenced by antibiotics. For this study, 1,133 patients (42.6%) had culture-positive sepsis vs 1,526 (56.4%) patients had culture-negative sepsis. According to the findings, a higher mortality rate was observed in relation to culture-positive sepsis. Having ≥ 3 organ systems affected during the sepsis episode correlated with culture-positive sepsis. Negative blood cultures were more likely in patients who received antibiotics at home vs those who did not.