Lane LC, Kuś A, Bednarczuk T, et al. - In the present study, the researchers sought to explore the correlation of the HLA complex P5 (HCP5) variant rs3094228 with Graves’ disease (GD) susceptibility and age of onset in a UK cohort and perform a meta-analysis of UK and Polish data. Using Taqman chemistry, rs3094228 was genotyped in 469 UK patients with GD. Using logistic regression analysis, genotype frequencies were contrasted to genotypic data available from the Wellcome Trust case-control consortium. According to findings, the rs3094228 HCP5 polymorphism is independently linked to GD susceptibility and age of onset in a UK GD cohort. The outcomes show a potential role for long non-coding RNAs, including HCP5, in GD pathogenesis, particularly among the younger population.