Toll RT, Wu W, Naparstek S, et al. - Researchers explored brain areas whose frequency-specific, orthogonalized resting-state EEG power envelope connectivity varies between combat veterans with posttraumatic stress disorder (PTSD) and healthy combat-exposed veterans. They also ascertained the behavioral correlates of connectomic variations. In PTSD, a significant reduction was identified in 74 brain region connections (all in the eyes-open condition and predominantly using the theta carrier frequency). The most prominent were: the underconnectivity of the orbital and anterior middle frontal gyri. In this study, findings revealed the presence of robust PTSD-associated abnormalities in theta-band source-space orthogonalized power envelope connectivity, which furthermore was found to be associated with cognitive deficits in these patients. A clinically relevant connectomic profile of PTSD was established in this study, employing a tool that promotes the lower-cost clinical translation of network connectivity research.