Martinez-Valbuena I, Valenti-Azcarate R, Amat-Villegas I, et al. - In this investigation, researchers ascertained if tau and Aβ deposits could occur in the pancreatic tissue of Alzheimer disease (AD) patients and whether amylin (an amyloidogenic protein deposited in the pancreas of type 2 diabetes mellitus [T2D] patients) could amass in AD patients' brains. Pancreatic and brain tissue were assessed in 48 people with no neuropathological alterations and in 87 patients with an AD diagnosis. According to results, cytoplasmic tau and Aβ protein deposits were discovered in the pancreatic β-cells of AD patients and in individuals with a normal neuropathological exam but with a history of T2D and a small cohort of T2D-free controls. They also discovered amylin deposits in the brains of these individuals, offering histological evidence that amylin in both the pancreas and hippocampus can interact with Aβ and tau. New evidence of possible overlap in mechanisms underlying T2D and AD pathogenesis is offered by the presence of tau and Aβ inclusions in pancreatic β cells, as well as amylin deposits in the brain.