Martinez-Valbuena I, Valenti-Azcarate R, Amat-Villegas I, et al. – Given the potential contributory role of type 2 diabetes (T2D) and other prediabetic states of insulin resistance in the development of sporadic Alzheimer disease (AD), researchers investigated the possible presence of tau and β-amyloid (Aβ) deposits in the pancreatic tissue of individuals with AD. They also investigated whether amylin—an amyloidogenic protein deposited in the pancreas of T2D patients—accumulate in the brains of patients with AD. Participants included 48 individuals with no neuropathological changes, and 87 patients with AD. The investigators analyzed pancreatic and brain tissue samples obtained from participants. In those with AD and those with normal neuropathological examination (but with a history of T2D) and in a small cohort of controls without T2D, they found the presence of cytoplasmic tau and Aβ protein deposits in pancreatic β cells. In addition, they detected amylin deposits in the brains of these individuals. These findings offer novel proof of potential overlap in the mechanisms underlying the pathogenesis of T2D and AD.