Barber TM, Bhatti AA, Elder PJD, et al. - Considering that the human amylase gene (AMY1) has broad copy number (CN) variation that may be correlated with BMI, researchers used Pearson Correlation Coefficients to analyze the correlation of AMY1 CN with comprehensive markers of metabolic status (ProFiMet cohort). DNA was taken from urine (n = 74) and serum (n = 6) samples (‘ProFiMet’ cohort), and buccal (n = 17) samples (Oral Starch Challenge [OSC] cohort), and evaluated for AMY1 CN by droplet digital PCR. Significant inverse correlations of AMY1 CN with total visceral fat volume, and positive correlations of AMY1 CN with oral glucose insulin sensitivity score, serum HDL-cholesterol, and serum adiponectin have occurred. No significant connections were found between AMY1 CN and clamp-derived M-value, homeostasis model assessment of insulin resistance (IR), hepatic endogenous glucose production, fecal floral signature, or macronutrient dietary preference. High AMY1 CN is associated with a favorable metabolic profile (lower visceral fat volume; higher serum adiponectin; enhanced glucose absorption following oral glucose and OSC), but not with whole-body or hepatic IR.