Lu Y, Chan YK, Lau LH, et al. - Researchers conducted this an eye-on-a-chip study to analyze the impact of amphiphilic additives in silicone oil on emulsification under eye-like movements. For this analysis, three silicone-oil-soluble surfactants, namely DC749, MQ1640 and FZ2233, were utilized as model amphiphilic additives. The authors discovered that emulsification was promoted by the amphiphilic substances in silicone oil. Water-in-oil drops were also formed in addition to typical oil-in-water drops that normally affect the eye. It is necessary to examine the nature of the drug and its possible impact on emulsification and therefore on pharmacokinetics before silicone oil could be regarded as a vehicle for drug delivery. Another concern is that water-in-oil droplets in the eye would affect silicone oil's optical clarity and may cause visual symptoms.